| Nexsen Pruet, LLC | Columbia, SC | $163M | 512 | 2024 |
| The Reliable Automatic Sprinkler, Co.,inc. | Liberty, SC | $37M | 439 | 2025 |
| Uci Medical Affiliates Of South Carolina, INC. | Columbia, SC | $34M | 495 | 2025 |
| Cornell Dubilier Electronics, INC. | Liberty, SC | $22M | 613 | 2024 |
| C.m. Tucker Lumber Companies, LLC | Pageland, SC | $21M | 376 | 2024 |
| Roper Emergency Physicians, PC | Mount Pleasant, SC | $21M | 49 | 2023 |
| Seibels Services Group, INC. | Columbia, SC | $20M | 206 | 2025 |
| Bradshaw Automotive Companies | Greer, SC | $19M | — | 2023 |
| Associates In Oral & Maxillofacial Surgery, PA | West Columbia, SC | $18M | 11 | 2024 |
| Rts Packaging, LLC | Hartville, SC | $16M | 294 | 2024 |
| Hybridge Solutions, INC. | Inman, SC | $15M | 124 | 2025 |
| Coastal Cardiology Associates PA | Charleston, SC | $14M | 83 | 2023 |
| Midlands Oral & Maxillofacial Surgery, P.A. | Columbia, SC | $11M | 35 | 2024 |
| Jear Logistics, LLC | Mt Pleasant, SC | $11M | 281 | 2025 |
| Denkai America INC. | Camden, SC | $10M | 221 | 2025 |
| Civil Engineering Consulting Services, INC. | Columbia, SC | $10M | 72 | 2025 |
| Vic Bailey Superstores, INC. | Greenville, SC | $9.9M | 42 | 2024 |
| Intramed Plus, INC. | West Columbia, SC | $8.7M | 179 | 2025 |
| Bradshaw, Gordon & Clinkscales, LLC | Greenville, SC | $8.6M | 60 | 2026 |
| Springfield Tool And Die, INC. | Duncan, SC | $8.5M | 23 | 2024 |
| Roofers Supply Of Greenville, INC. | Greenville, SC | $8.0M | 39 | 2024 |
| Richard E. Boyd, D.m.d, M.s., P.A. | Columbia, SC | $7.8M | 31 | 2024 |
| Greenwood Ent Association, PA | Greenwood, SC | $7.7M | 31 | 2024 |
| Allergy And Asthma Consultants, L.L.P. | Mt.pleasant, SC | $7.3M | 36 | 2023 |
| Howard F. Vincent, Jr., Dmd, PA | Charleston, SC | $7.2M | 2 | 2025 |
| Palmetto Internal Medicine, P.A. | Columbia, SC | $5.8M | 2 | 2025 |
| Carolina Cardiology Associates, P.A. | Rock Hill, SC | $5.7M | 65 | 2024 |
| The P.m. Group Of Columbia, INC. | Columbia, SC | $5.6M | 12 | 2025 |
| Carolina Medical Consultants, P.A. | Rock Hill, SC | $5.5M | 26 | 2024 |
| Rural Spine Care, P.C. | Bluffton, SC | $5.3M | 3 | 2024 |
| Rheumatology Associates, P.A. | Charleston, SC | $5.1M | 24 | 2025 |