| Nexsen Pruet, LLC | Columbia, SC | $163M | 512 | 2024 |
| Anesthesiology of Greenwood, P.A. | Greenwood, SC | $39M | 37 | 2024 |
| Uci Medical Affiliates of South Carolina, Inc. | Columbia, SC | $34M | 495 | 2025 |
| Cornell Dubilier Electronics, Inc. | Liberty, SC | $22M | 613 | 2024 |
| C.M. Tucker Lumber Companies, LLC | Pageland, SC | $21M | 376 | 2024 |
| Roper Emergency Physicians, PC | Mount Pleasant, SC | $21M | 49 | 2023 |
| Seibels Services Group, Inc. | Columbia, SC | $20M | 206 | 2025 |
| Bradshaw Automotive Companies | Greer, SC | $19M | 440 | 2023 |
| Associates In Oral & Maxillofacial Surgery, PA | West Columbia, SC | $18M | 11 | 2024 |
| Rts Packaging, LLC | Hartville, SC | $16M | 294 | 2024 |
| Hybridge Solutions, Inc. | Inman, SC | $15M | 124 | 2025 |
| Coastal Cardiology Associates PA | Charleston, SC | $14M | 83 | 2023 |
| Midlands Oral & Maxillofacial Surgery, P.A. | Columbia, SC | $11M | 35 | 2024 |
| Jear Logistics, LLC | Mt Pleasant, SC | $11M | 281 | 2025 |
| Denkai America Inc. | Camden, SC | $10M | 221 | 2025 |
| Civil Engineering Consulting Services, Inc. | Columbia, SC | $10M | 72 | 2025 |
| Charleston Emergency Services, LLC | Mt. Pleasant, SC | $9.9M | 20 | 2023 |
| Vic Bailey Superstores, Inc. | Greenville, SC | $9.9M | 42 | 2024 |
| Printgear Sportswear Distributors | Cayce, SC | $9.1M | 25 | 2025 |
| Intramed Plus, Inc. | West Columbia, SC | $8.7M | 179 | 2025 |
| Bradshaw, Gordon & Clinkscales, LLC | Greenville, SC | $8.6M | 60 | 2026 |
| Springfield Tool and Die, Inc. | Duncan, SC | $8.5M | 23 | 2024 |
| Charles R. Chitwood | Summerville, SC | $8.0M | 12 | 2026 |
| Roofers Supply of Greenville, Inc. | Greenville, SC | $8.0M | 39 | 2024 |
| Richard E. Boyd, D.M.D, M.S., P.A. | Columbia, SC | $7.8M | 31 | 2024 |
| Mims, McDuff & Wood, P.A. | Beaufort, SC | $7.7M | 14 | 2025 |
| Greenwood Ent Association, PA | Greenwood, SC | $7.7M | 31 | 2024 |
| Florence Neurosurgery & Spine, PC | Florence, SC | $7.3M | 48 | 2023 |
| Allergy and Asthma Consultants, L.L.P. | Mt.pleasant, SC | $7.3M | 36 | 2023 |
| Howard F. Vincent, Jr., DMD, PA | Charleston, SC | $7.2M | 2 | 2025 |
| Keenan Energy Company | Columbia, SC | $6.9M | 51 | 2026 |
| Coastal Carolina Urology Group, LLC | Beaufort, SC | $6.8M | 12 | 2025 |
| Georgetown Radiology, LLC | Pawleys Island, SC | $6.5M | 3 | 2026 |
| J. Michele Boyne, DMD, LLC | Rock Hill, SC | $6.0M | 9 | 2025 |
| Manley Garvin, LLC | Greenwood, SC | $5.9M | 35 | 2026 |
| Ground Swell Capital LLC | Folly Beach, SC | $5.9M | 10 | 2025 |
| Palmetto Internal Medicine, P.A. | Columbia, SC | $5.8M | 2 | 2025 |
| Carolina Cardiology Associates, P.A. | Rock Hill, SC | $5.7M | 65 | 2024 |
| Upstate Oral & Maxillofacial Surgery & Dental Implant Center,p.a | Easley, SC | $5.7M | 25 | 2023 |
| The P.M. Group of Columbia, Inc. | Columbia, SC | $5.6M | 12 | 2025 |
| Carolina Medical Consultants, P.A. | Rock Hill, SC | $5.5M | 26 | 2024 |
| Rural Spine Care, P.C. | Bluffton, SC | $5.3M | 3 | 2024 |
| Lakeview Internal Medicine, PA | Seneca, SC | $5.1M | 6 | 2025 |
| Rheumatology Associates, P.A. | Charleston, SC | $5.1M | 24 | 2025 |